Research in the field of Quantum dots
Quantum dots (QDs), with superior optical properties of extreme brightness and photobleaching resistance, have attracted further attention in recent ten years as an alternative to traditional organic dyes for biomedical imaging. We focus on designing and fabricating QDs that are specific to label endothelial progenitor cells (EPCs) and to functionalize QDs with vascular cell adhesion molecule-1 (VCAM-1) binding peptides for targeting VCAM-1-expressed cells for molecular imaging and studying early-stage atherosclerosis, human airway epithelial cells (Calu-3) for lung health study, in close collaborations of KTH, AstraZeneca and Sahlgrenska University Hospital.
The research team has extensive experience and knowledge regarding design and fabrication of colloidal QDs, bioconjugating and imaging QDs, and cell culture. The team has a chemical lab where QD-based nanostructures are fabricated and characterized and access to various state-of-art bioimaging facilities at the Department of Applied Physics (KTH) and the Bioimaging Platform of SciLifeLab. The use of colloidal quantum dots (QDs) is one of the most exciting developments in nanobiotechnology. Because of their high durability and unique optical properties QDs are widely used as fluorescent labelling agents for in vitro and in vivo bioimaging, such as cell labeling, deep tissue imaging, and fluorescent resonance energy transfer donors. Surface modified and water-soluble QDs open a new era in cell imaging and biotargeting.