Cellular Biophysics

Our laboratory is a multidisciplinary combination of the Cellular Biophysics research group from KTH and the Pediatric Cell and Molecular Biology group from KI. The laboratory is located at the Science for Life Laboratory, Solna, Stockholm. We use an interdisciplinary and translational approach to address questions of high medical relevance. Our biophysical emphasis is on cellular biophysics, advanced light microscopy and nanobiophotonics - nanoscopy.

Research areas:

Brismar group - Bioimaging

Our biomedical emphasis is on the molecular origin for some pediatric and neuropsychiatric diseases. 

The main topic in our research is to understand the many functional aspects of Na+,K+-ATPase, the salt pump that is the major determinant of intracellular ion homeostasis and which has recently been shown to also function as a signal transducer.

Testa group - Live Superresolution

We are a group with cross disciplinarians expertise in physics, biology and chemistry, which aims to push the spatio-temporal resolution of light microscopy to advance the life sciences.

 Structural and functional studies at the subcellular level call for observation of nanosized, highly sensitive features. 

 Our STED/RESOLFT cutting edge technology enable and push forward the live cell imaging ability of super resolution microscopy by minimizing photo-toxicity and recording time. 

We take advantage and develope further super resolution optical microscopy to study neuronal protein organization and dynamics in brain cells and tissues.

Önfelt group - Cell screening

Our research focus on the immune system and in particular NK and T cells. The lab is multidisciplinary and combines biology and technology.  One of the immediate goals of our research is to implement new tools and single cell assays that can be used in academic research, hospitals or in pharmacological industry for immune cell diagnostics, applications within stem cell transplantation and cellular therapy.

Fu group - Quantum dots

Quantum dots, when you want to see more for a longer time... The use of colloidal quantum dots (QDs) is one of the most exciting developments in nanobiotechnology. Because of their high durability and unique optical properties QDs are widely used as fluorescent labelling agents for in vitro and in vivo bioimaging, such as cell labeling, deep tissue imaging, and fluorescent resonance energy transfer donors. Surface modified and water-soluble QDs open a new era in cell imaging and biotargeting.

National Research Facility - Advanced Ligth Microscopy

The Advanced Light Microscopy (ALM) facility give open-access to state-of-the art superresolution fluorescence microscopy for nanoscale biological visualization - nanoscopy. The facility offers access to super-resolution techniques (STED, PALM/STORM, SIM) and to experimental techniques such as easy-STED and QD-SPT. For more information and access see  www.scilifelab.se/facilities/alm .

All our systems are now upgraded to 3D functionality (3D-STED, 3D-PALM, 3D-SIM)


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