Hard x-ray bio imaging

Senior scientist(s): Hans Hertz, Anna Burvall

X-ray imaging technologies are essential for life science, from basic research to clinical practice. Novel modalities such as, e.g., phase-contrast imaging [1], shows promise for higher spatial resolution and improved contrast while still operating with an acceptable dose. Many imaging methods are source limited.

We invented the liquid-metal-jet-anode hard x-ray source [2]. This compact electron-impact microfocus source potentially allows for more than 100´ higher brightness than any competing laboratory x-ray tube. We exploit the unique high spatial coherence of the source for very-high-resolution propagation-based phase-contrast imaging at low dose [3]. Present emphasis is on microangiography in mouse, demonstrating detection of sub-10 mm diam vessels. Recently the method was extended to imaging of intact tumor microvasculature (cf. Fig. 1) [4] as well as to whole-body mouse CT. Present work focus on phase-retrieval, soft-tissue imaging, and x-ray fluorescence.

References

  1. See, e.g., F. Pfeiffer et. al, Natute Phys 2, 258 (2006).
  2. O. Hemberg et al, Appl. Phys. Lett. 83, 1483 (2003).
  3. T. Tiuhimaa et al, Appl. Phys. Lett. 91, 074104 (2007).
  4. U. Lundstrom et al, Phys Med Biol. 59, 2801-11 (2014).
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