Hard x-ray bio imaging
Senior scientist(s): Hans Hertz, Anna Burvall
X-ray imaging technologies are essential for life science, from basic research to clinical practice. Novel modalities such as, e.g., phase-contrast imaging , shows promise for higher spatial resolution and improved contrast while still operating with an acceptable dose. Many imaging methods are source limited.
We invented the liquid-metal-jet-anode hard x-ray source . This compact electron-impact microfocus source potentially allows for more than 100´ higher brightness than any competing laboratory x-ray tube. We exploit the unique high spatial coherence of the source for very-high-resolution propagation-based phase-contrast imaging at low dose . Past projects include, e.g., microangiography in mouse, demonstrating detection of sub-10 mm diam vessels. The method was also extended to imaging of intact tumor microvasculature (cf. Fig. 1)  as well as to whole-body mouse CT. Current projects are:
Propagation-based phase-contrast imaging
Present work focus on high-resolution soft-tissue imaging [5,6] and phase retrieval . Our most recent study concerns imaging of ancient tissue in the form of a 2500 years old mummy hand (see Fig. 2) .
X-ray fluorescence tomography
X-ray fluorescence (XRF) is used for 3D molecular imaging. We have developted a laboratory system for high-resolution imaging of small animals.
We have master thesis projects available in both phase-contrast imaging and XRF. For more information, please contact Hans Hertz at firstname.lastname@example.org.
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- W. Vågberg et al, Sci Rep. 8, 11014 (2018).
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