Illuminating biology at the nanoscale and systems scale using single-molecule and super-resolution imaging
Time: Fri 2017-10-13 09.00
Lecturer: Dr. Xiaowei Zhuang, HHMI Investigator and David B. Arnold Professor of Science at Harvard University
Location: Air&Fire, SciLifelab
Xiaowei Zhuang develops advanced imaging techniques, in particular single-molecule and super-resolution imaging methods, to study problems of biomedical interest. She invented a super-resolution imaging method, STORM, which overcomes the diffraction limit using switching and localization of single fluorescent molecules. She continues to push the envelope of super-resolution imaging by increasing the spatiotemporal resolution and enabling in vivo imaging. Recently, she invented a multiplexed, error-robust fluorescence in situ hybridization (MERFISH) method for transcriptome imaging. She applies these methods to investigating a variety of biological problems, including the molecular structures inside neurons and neuronal connectivity in circuits, the three-dimensional organization of chromatin and chromosomes in the nucleus, and the regulation of gene expression.