Our laboratory is a multidisciplinary combination of the Cellular Biophysics research group from KTH and the Pediatric Cell and Molecular Biology group from KI. The laboratory is located at the Science for Life Laboratory, Solna, Stockholm. We use an interdisciplinary and translational approach to address questions of high medical relevance. Our biophysical emphasis is on cellular biophysics, advanced light microscopy and nanobiophotonics - nanoscopy.
Our biomedical emphasis is on the molecular origin for some pediatric and neuropsychiatric diseases.
The main topic in our research is to understand the many functional aspects of Na+,K+-ATPase, the salt pump that is the major determinant of intracellular ion homeostasis and which has recently been shown to also function as a signal transducer.
Our research interest is focused on the establishment and development of advanced light microscopy techniques and its application to the life sciences.
Fluorescence microscopes, and especially their confocal and two-photon variants, are unique in their ability to directly observe morphological changes and molecular reactions in living cells. By controlling those properties in space or time with light it is possible to improve the spatial resolution of an optical microscope down to the molecular scale (10-20nm).
Our research focus on the immune system and in particular NK and T cells. The lab is multidisciplinary and combines biology and technology. One of the immediate goals of our research is to implement new tools and single cell assays that can be used in academic research, hospitals or in pharmacological industry for immune cell diagnostics, applications within stem cell transplantation and cellular therapy.
Quantum dots, when you want to see more for a longer time... The use of colloidal quantum dots (QDs) is one of the most exciting developments in nanobiotechnology. Because of their high durability and unique optical properties QDs are widely used as fluorescent labelling agents for in vitro and in vivo bioimaging, such as cell labeling, deep tissue imaging, and fluorescent resonance energy transfer donors. Surface modified and water-soluble QDs open a new era in cell imaging and biotargeting.
National Research Facility - Advanced Ligth Microscopy
The Advanced Light Microscopy (ALM) facility give open-access to state-of-the art superresolution fluorescence microscopy for nanoscale biological visualization - nanoscopy. The facility offers access to super-resolution techniques (STED, PALM/STORM, SIM) and to experimental techniques such as easy-STED and QD-SPT. For more information and access see
All our systems are now upgraded to 3D functionality (3D-STED, 3D-PALM, 3D-SIM)
In our laboratory we develop methods based on STED, PALM, dSTORM and SIM super resolution microscopy - nanoscopy. We operate the Swedish national infrastructure for super resolution microscopy within Science for Life Laboratory with competence support and free and open access for swedish and international researchers.