Hard x-ray bio imaging
Senior scientist(s): Hans Hertz, Anna Burvall
X-ray imaging technologies are essential for life science, from basic research to clinical practice. Novel modalities such as, e.g., phase-contrast imaging , shows promise for higher spatial resolution and improved contrast while still operating with an acceptable dose. Many imaging methods are source limited.
We invented the liquid-metal-jet-anode hard x-ray source . This compact electron-impact microfocus source potentially allows for more than 100´ higher brightness than any competing laboratory x-ray tube. We exploit the unique high spatial coherence of the source for very-high-resolution propagation-based phase-contrast imaging at low dose . Present emphasis is on microangiography in mouse, demonstrating detection of sub-10 mm diam vessels. Recently the method was extended to imaging of intact tumor microvasculature (cf. Fig. 1)  as well as to whole-body mouse CT. Present work focus on phase-retrieval, soft-tissue imaging, and x-ray fluorescence.
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